Mechanisms of neurodegeneration due to glycosyltransferase dysfunction

Takeaway

  • This review presents substantial evidence for the role of glycosyltransferase dysfunction in development of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), Parkinson’s disease, Huntington’s disease, and Alzheimer’s disease.

Why this matters

    Glycosyltransferases are likely to be important in the future development of targeted therapies for neurodegenerative diseases.