Impulsive-compulsive behavior and dopamine replacement therapy in Parkinson’s disease

Takeaway

  • In people with Parkinson’s disease (PD) undergoing dopamine replacement therapy (DRT), impulse-control is affected by a reduction of mesolimbic projections and weak fronto-striatal connectivity rather than a downregulation of dopamine transporters.

Why this matters

  • People with PD undergoing DRT may be predisposed to impulsive-compulsive behavior (ICB) and it is crucial to assess the neurobiological risk of ICB associated with DRT.