Identification of a cellular mechanism for reduced cortical blood flow in models of Alzheimer's disease

Takeaway

  • Neutrophil adhesion in brain capillaries contributes to reduced cortical cerebral blood flow (cCBF) and impaired memory function in murine models of Alzheimer’s disease.

Why this matters ?

  • Vascular dysfunction is implicated in Alzheimer’s disease and is thought to contribute to cognitive dysfunction – uncovering the cellular basis for reduced cCBF could lead to promising therapeutic approaches.