Disease-specific patterns of brain injury in pediatric-onset multiple sclerosis

Takeaway

  • A ‘surface-in’ gradient of thalamic damage on the ventricular side is present at clinical presentation in children with multiple sclerosis (MS) but not monophasic acquired demyelinating syndromes (monoADS).

Why this matters

  • This pattern of brain injury might reflect the very early presence of non-relapsing progressive MS pathology, with important implications for treatment decisions.