Cortical thickness in sporadic Creutzfeldt-Jakob disease

Takeaway

  • People with sporadic Creutzfeldt-Jakob disease (sCJD) have reduced cortical thickness in multiple brain regions of interest (ROI), and these changes do not correlate with disease duration or clinical markers of disease.

Why this matters ?

  • A better understanding of brain topography in sCJD is required to inform clinical care and, potentially, to develop therapeutic strategies that arrest spread within the brain.