Characterization of spinal cord damage in a marmoset model of multiple sclerosis

Takeaway

  • Symptomatic marmosets with experimental autoimmune encephalomyelitis (EAE) display spinal cord (SC) focal lesions typical of those seen in people with multiple sclerosis (MS), as well as subpial lesions, and these correspond with areas of demyelination and inflammation.

Why this matters

  • This study establishes that EAE in the marmoset is a relevant model for studying the mechanisms of SC lesion formation in MS.